Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex

Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the quaternary nature of...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sok, Devin, van Gils, Marit J., Pauthner, Matthias, Julien, Jean-Philippe, Saye-Francisco, Karen L., Hsueh, Jessica, Briney, Bryan, Lee, Jeong Hyun, Le, Khoa M., Lee, Peter S., Hua, Yuanzi, Seaman, Michael S., Moore, John P., Ward, Andrew B., Wilson, Ian A., Sanders, Rogier W., Burton, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267403/
https://ncbi.nlm.nih.gov/pubmed/25422458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415789111
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