A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env) trimer. Using cryo-electron microscopy, we solved the atomic structure of an a...

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Pubblicato in:Immunity
Autori principali: Lee, Jeong Hyun, Andrabi, Raiees, Su, Ching-Yao, Yasmeen, Anila, Julien, Jean-Philippe, Kong, Leopold, Wu, Nicholas C., McBride, Ryan, Sok, Devin, Pauthner, Matthias, Cottrell, Christopher A., Nieusma, Travis, Blattner, Claudia, Paulson, James C., Klasse, Per Johan, Wilson, Ian A., Burton, Dennis R., Ward, Andrew B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400778/
https://ncbi.nlm.nih.gov/pubmed/28423342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.03.017
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