A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic β-Hairpin Structure

Broadly neutralizing antibodies (bnAbs) to HIV delineate vaccine targets and are prophylactic and therapeutic agents. Some of the most potent bnAbs target a quaternary epitope at the apex of the surface HIV envelope (Env) trimer. Using cryo-electron microscopy, we solved the atomic structure of an a...

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Vydáno v:Immunity
Hlavní autoři: Lee, Jeong Hyun, Andrabi, Raiees, Su, Ching-Yao, Yasmeen, Anila, Julien, Jean-Philippe, Kong, Leopold, Wu, Nicholas C., McBride, Ryan, Sok, Devin, Pauthner, Matthias, Cottrell, Christopher A., Nieusma, Travis, Blattner, Claudia, Paulson, James C., Klasse, Per Johan, Wilson, Ian A., Burton, Dennis R., Ward, Andrew B.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400778/
https://ncbi.nlm.nih.gov/pubmed/28423342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2017.03.017
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