Crystal structure of a soluble cleaved HIV-1 envelope trimer

HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env) trimers that have been challenging to characterize structurally. Here, we describe the crystal structure at 4.7 Å of an antigenically near-native, cleaved, stabilized, soluble Env trimer (termed BG505 SOSIP.664 gp1...

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Detalhes bibliográficos
Main Authors: Julien, Jean-Philippe, Cupo, Albert, Sok, Devin, Stanfield, Robyn L., Lyumkis, Dmitry, Deller, Marc C., Klasse, Per-Johan, Burton, Dennis R., Sanders, Rogier W., Moore, John P., Ward, Andrew B., Wilson, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3886632/
https://ncbi.nlm.nih.gov/pubmed/24179159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1245625
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