ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles

The most common mutation causing cystic fibrosis (CF) is deletion of phenylalanine residue 508 in the cystic fibrosis transmembrane regulator conductance (CFTR) protein. Small molecules that are able to correct the misfolding of defective ΔF508-CFTR have considerable promise for therapy. Reported he...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Autores principales: Ye, Long, Hu, Bao, El-Badri, Faris, Hudson, Brandi M., Phuan, Puay-Wah, Verkman, A. S., Tantillo, Dean J., Kurth, Mark J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255153/
https://ncbi.nlm.nih.gov/pubmed/25452003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.067
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares