ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles

The most common mutation causing cystic fibrosis (CF) is deletion of phenylalanine residue 508 in the cystic fibrosis transmembrane regulator conductance (CFTR) protein. Small molecules that are able to correct the misfolding of defective ΔF508-CFTR have considerable promise for therapy. Reported he...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Bioorg Med Chem Lett
Main Authors: Ye, Long, Hu, Bao, El-Badri, Faris, Hudson, Brandi M., Phuan, Puay-Wah, Verkman, A. S., Tantillo, Dean J., Kurth, Mark J.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255153/
https://ncbi.nlm.nih.gov/pubmed/25452003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.067
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares