ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles

The most common mutation causing cystic fibrosis (CF) is deletion of phenylalanine residue 508 in the cystic fibrosis transmembrane regulator conductance (CFTR) protein. Small molecules that are able to correct the misfolding of defective ΔF508-CFTR have considerable promise for therapy. Reported he...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Ye, Long, Hu, Bao, El-Badri, Faris, Hudson, Brandi M., Phuan, Puay-Wah, Verkman, A. S., Tantillo, Dean J., Kurth, Mark J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4255153/
https://ncbi.nlm.nih.gov/pubmed/25452003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.09.067
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