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Initial Testing (Stage 1) of the Notch Inhibitor PF-03084014, by the Pediatric Preclinical Testing Program
PF-03084014, a γ-secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0 nM to 10 μM) and against the in vivo xenograft panels (administered orally twice daily on days 1–7 and 15–21). PF-03084014 demonstrated limited in vitro activity, with no cell line achieving ≥50% inhibiti...
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| Publicat a: | Pediatr Blood Cancer |
|---|---|
| Autors principals: | , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4225044/ https://ncbi.nlm.nih.gov/pubmed/24664981 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25026 |
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