Initial Testing (Stage 1) of BAL101553, a Novel Tubulin Binding Agent, by the Pediatric Preclinical Testing Program

BAL101553 is a highly water soluble prodrug of BAL27862 that arrests tumor cell proliferation and induces cell death in cancer cells through disruption of the microtubule network. In vitro BAL27862 demonstrated potent activity, with the median relative IC(50) (rIC(50)) of 13.8 nM (range 5.4 to 25.2...

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Publicat a:Pediatr Blood Cancer
Autors principals: Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Maris, John M., Kang, Min H., Reynolds, C. Patrick, Lock, Richard B., Carol, Hernan, Wu, Jianrong, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405429/
https://ncbi.nlm.nih.gov/pubmed/25407467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25329
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