Initial Testing (Stage 1) of BAL101553, a Novel Tubulin Binding Agent, by the Pediatric Preclinical Testing Program

BAL101553 is a highly water soluble prodrug of BAL27862 that arrests tumor cell proliferation and induces cell death in cancer cells through disruption of the microtubule network. In vitro BAL27862 demonstrated potent activity, with the median relative IC(50) (rIC(50)) of 13.8 nM (range 5.4 to 25.2...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pediatr Blood Cancer
Prif Awduron: Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Maris, John M., Kang, Min H., Reynolds, C. Patrick, Lock, Richard B., Carol, Hernan, Wu, Jianrong, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405429/
https://ncbi.nlm.nih.gov/pubmed/25407467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25329
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