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Initial Testing (Stage 1) of the Notch Inhibitor PF-03084014, by the Pediatric Preclinical Testing Program

PF-03084014, a γ-secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0 nM to 10 μM) and against the in vivo xenograft panels (administered orally twice daily on days 1–7 and 15–21). PF-03084014 demonstrated limited in vitro activity, with no cell line achieving ≥50% inhibiti...

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Библиографические подробности
Опубликовано в: :Pediatr Blood Cancer
Главные авторы: Carol, Hernan, Maris, John M., Kang, Min H., Reynolds, C. Patrick, Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Wu, Jianrong, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225044/
https://ncbi.nlm.nih.gov/pubmed/24664981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25026
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