Initial Testing (Stage 1) of the Notch Inhibitor PF-03084014, by the Pediatric Preclinical Testing Program

PF-03084014, a γ-secretase inhibitor, was tested against the PPTP in vitro cell line panel (1.0 nM to 10 μM) and against the in vivo xenograft panels (administered orally twice daily on days 1–7 and 15–21). PF-03084014 demonstrated limited in vitro activity, with no cell line achieving ≥50% inhibiti...

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Detalhes bibliográficos
Publicado no:Pediatr Blood Cancer
Main Authors: Carol, Hernan, Maris, John M., Kang, Min H., Reynolds, C. Patrick, Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Wu, Jianrong, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A., Lock, Richard B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4225044/
https://ncbi.nlm.nih.gov/pubmed/24664981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25026
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