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Initial Testing (Stage 1) of BAL101553, a Novel Tubulin Binding Agent, by the Pediatric Preclinical Testing Program
BAL101553 is a highly water soluble prodrug of BAL27862 that arrests tumor cell proliferation and induces cell death in cancer cells through disruption of the microtubule network. In vitro BAL27862 demonstrated potent activity, with the median relative IC(50) (rIC(50)) of 13.8 nM (range 5.4 to 25.2...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Pediatr Blood Cancer |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4405429/ https://ncbi.nlm.nih.gov/pubmed/25407467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25329 |
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