Initial Testing (Stage 1) of BAL101553, a Novel Tubulin Binding Agent, by the Pediatric Preclinical Testing Program

BAL101553 is a highly water soluble prodrug of BAL27862 that arrests tumor cell proliferation and induces cell death in cancer cells through disruption of the microtubule network. In vitro BAL27862 demonstrated potent activity, with the median relative IC(50) (rIC(50)) of 13.8 nM (range 5.4 to 25.2...

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Detaylı Bibliyografya
Yayımlandı:Pediatr Blood Cancer
Asıl Yazarlar: Kolb, E. Anders, Gorlick, Richard, Keir, Stephen T., Maris, John M., Kang, Min H., Reynolds, C. Patrick, Lock, Richard B., Carol, Hernan, Wu, Jianrong, Kurmasheva, Raushan T., Houghton, Peter J., Smith, Malcolm A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4405429/
https://ncbi.nlm.nih.gov/pubmed/25407467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.25329
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