Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells

In vivo visualization of thrombopoiesis suggests an important role for shear flow in platelet biogenesis. In vitro, shear stress was shown to accelerate proplatelet formation from mature megakaryocytes (Mks). Yet, the role of biomechanical forces on Mk biology and platelet biogenesis remains largely...

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Hlavní autoři: Jiang, Jinlin, Woulfe, Donna S., Papoutsakis, Eleftherios T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2014
Témata:
Platelets and Thrombopoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186538/
https://ncbi.nlm.nih.gov/pubmed/24948658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-547927
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