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Engineering human megakaryocytic microparticles for targeted delivery of nucleic acids to hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs) are important target cells for gene therapy applications. Current genetic modifications of HSPCs rely on viral vectors in vivo or electroporation ex vivo. Here, we developed a nonviral system based on megakaryocytic microparticles (MPs) for targeted de...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Kao, Chen-Yuan, Papoutsakis, Eleftherios T.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6221511/
https://ncbi.nlm.nih.gov/pubmed/30417099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aau6762
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