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Shear enhances thrombopoiesis and formation of microparticles that induce megakaryocytic differentiation of stem cells

In vivo visualization of thrombopoiesis suggests an important role for shear flow in platelet biogenesis. In vitro, shear stress was shown to accelerate proplatelet formation from mature megakaryocytes (Mks). Yet, the role of biomechanical forces on Mk biology and platelet biogenesis remains largely...

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書誌詳細
主要な著者: Jiang, Jinlin, Woulfe, Donna S., Papoutsakis, Eleftherios T.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186538/
https://ncbi.nlm.nih.gov/pubmed/24948658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-01-547927
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