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Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8
[Image: see text] The lysine methyltransferase SETD8 is the only known methyltransferase that catalyzes monomethylation of histone H4 lysine 20 (H4K20). Monomethylation of H4K20 has been implicated in regulating diverse biological processes including the DNA damage response. In addition to H4K20, SE...
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| 主要な著者: | , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Chemical
Society
2014
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| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4136711/ https://ncbi.nlm.nih.gov/pubmed/25032507 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500871s |
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