Structure Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase

Selective inhibitors of protein lysine methyltransferases, including SET domain-containing protein 8 (SETD8), are highly desired, as only a fraction of these enzymes are associated with high-quality inhibitors. From our previously discovered SETD8 inhibitor, we developed a more potent analog and sol...

Full description

Saved in:
Bibliographic Details
Published in:J Med Chem
Main Authors: Butler, Kyle V., Ma, Anqi, Yu, Wenyu, Li, Fengling, Tempel, Wolfram, Babault, Nicolas, Pittella-Silva, Fabio, Shao, Jason, Wang, Junyi, Luo, Minkui, Vedadi, Masoud, Brown, Peter J., Arrowsmith, Cheryl H., Jin, Jian
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148670/
https://ncbi.nlm.nih.gov/pubmed/27804297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b01244
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items