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Evaluation of class I HDAC isoform selectivity of largazole analogues
Largazole is a potent class I selective histone deacetylase (HDAC) inhibitor. The majority of largazole analogues to date have modified the thiazole-thiazoline and the warhead moiety. In order to elucidate class I-specific structure–activity relationships, a series of analogues with modifications in...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2014
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4135083/ https://ncbi.nlm.nih.gov/pubmed/25070421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.006 |
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