Evaluation of class I HDAC isoform selectivity of largazole analogues

Largazole is a potent class I selective histone deacetylase (HDAC) inhibitor. The majority of largazole analogues to date have modified the thiazole-thiazoline and the warhead moiety. In order to elucidate class I-specific structure–activity relationships, a series of analogues with modifications in...

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Autors principals: Kim, Bumki, Park, Heekwang, Salvador, Lilibeth A., Serrano, Patrick E., Kwan, Jason C., Zeller, Sabrina L., Chen, Qi-Yin, Ryu, Soyoung, Liu, Yanxia, Byeon, Seongrim, Luesch, Hendrik, Hong, Jiyong
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4135083/
https://ncbi.nlm.nih.gov/pubmed/25070421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.006
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