Tubulin polymerization disrupts cardiac β-adrenergic regulation of late I(Na)

AIMS: The anticancer drug paclitaxel (TXL) that polymerizes microtubules is associated with arrhythmias and sinus node dysfunction. TXL can alter membrane expression of Na channels (Na(V)1.5) and Na current (I(Na)), but the mechanisms are unknown. Calcium/calmodulin-dependent protein kinase II (CaMK...

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Main Authors: Dybkova, Nataliya, Wagner, Stefan, Backs, Johannes, Hund, Thomas J., Mohler, Peter J., Sowa, Thomas, Nikolaev, Viacheslav O., Maier, Lars S.
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133594/
https://ncbi.nlm.nih.gov/pubmed/24812278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu120
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