Tubulin polymerization disrupts cardiac β-adrenergic regulation of late I(Na)

AIMS: The anticancer drug paclitaxel (TXL) that polymerizes microtubules is associated with arrhythmias and sinus node dysfunction. TXL can alter membrane expression of Na channels (Na(V)1.5) and Na current (I(Na)), but the mechanisms are unknown. Calcium/calmodulin-dependent protein kinase II (CaMK...

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Bibliografske podrobnosti
Main Authors: Dybkova, Nataliya, Wagner, Stefan, Backs, Johannes, Hund, Thomas J., Mohler, Peter J., Sowa, Thomas, Nikolaev, Viacheslav O., Maier, Lars S.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133594/
https://ncbi.nlm.nih.gov/pubmed/24812278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu120
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