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Nanoimages show disruption of tubulin polymerization by chlorpyrifos oxon; implications for neurotoxicity

Organophosphorus agents cause cognitive deficits and depression in some people. We hypothesize that the mechanism by which organophosphorus agents cause these disorders is by modification of proteins in the brain. One such protein could be tubulin. Tubulin polymerizes to make the microtubules that t...

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Autores principales: Grigoryan, Hasmik, Lockridge, Oksana
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753691/
https://ncbi.nlm.nih.gov/pubmed/19631231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.07.015
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