Mice Treated with Chlorpyrifos or Chlorpyrifos Oxon Have Organophosphorylated Tubulin in the Brain and Disrupted Microtubule Structures, Suggesting a Role for Tubulin in Neurotoxicity Associated with Exposure to Organophosphorus Agents

Exposure to organophosphorus (OP) agents can lead to learning and memory deficits. Disruption of axonal transport has been proposed as a possible explanation. Microtubules are an essential component of axonal transport. In vitro studies have demonstrated that OP agents react with tubulin and disrupt...

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Библиографические подробности
Главные авторы: Jiang, Wei, Duysen, Ellen G., Hansen, Heidi, Shlyakhtenko, Luda, Schopfer, Lawrence M., Lockridge, Oksana
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2010
Предметы:
Neurotoxicology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855355/
https://ncbi.nlm.nih.gov/pubmed/20142434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq032
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