Mice Treated with Chlorpyrifos or Chlorpyrifos Oxon Have Organophosphorylated Tubulin in the Brain and Disrupted Microtubule Structures, Suggesting a Role for Tubulin in Neurotoxicity Associated with Exposure to Organophosphorus Agents

Exposure to organophosphorus (OP) agents can lead to learning and memory deficits. Disruption of axonal transport has been proposed as a possible explanation. Microtubules are an essential component of axonal transport. In vitro studies have demonstrated that OP agents react with tubulin and disrupt...

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Bibliographic Details
Main Authors: Jiang, Wei, Duysen, Ellen G., Hansen, Heidi, Shlyakhtenko, Luda, Schopfer, Lawrence M., Lockridge, Oksana
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Neurotoxicology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855355/
https://ncbi.nlm.nih.gov/pubmed/20142434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq032
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