Mice Treated with Chlorpyrifos or Chlorpyrifos Oxon Have Organophosphorylated Tubulin in the Brain and Disrupted Microtubule Structures, Suggesting a Role for Tubulin in Neurotoxicity Associated with Exposure to Organophosphorus Agents

Exposure to organophosphorus (OP) agents can lead to learning and memory deficits. Disruption of axonal transport has been proposed as a possible explanation. Microtubules are an essential component of axonal transport. In vitro studies have demonstrated that OP agents react with tubulin and disrupt...

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Bibliografiske detaljer
Main Authors: Jiang, Wei, Duysen, Ellen G., Hansen, Heidi, Shlyakhtenko, Luda, Schopfer, Lawrence M., Lockridge, Oksana
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Neurotoxicology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855355/
https://ncbi.nlm.nih.gov/pubmed/20142434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq032
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