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Tubulin polymerization disrupts cardiac β-adrenergic regulation of late I(Na)

AIMS: The anticancer drug paclitaxel (TXL) that polymerizes microtubules is associated with arrhythmias and sinus node dysfunction. TXL can alter membrane expression of Na channels (Na(V)1.5) and Na current (I(Na)), but the mechanisms are unknown. Calcium/calmodulin-dependent protein kinase II (CaMK...

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書誌詳細
主要な著者: Dybkova, Nataliya, Wagner, Stefan, Backs, Johannes, Hund, Thomas J., Mohler, Peter J., Sowa, Thomas, Nikolaev, Viacheslav O., Maier, Lars S.
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4133594/
https://ncbi.nlm.nih.gov/pubmed/24812278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvu120
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