ROS-activated Ca/calmodulin kinase IIδ is required for late I(Na) augmentation leading to cellular Na and Ca overload

RATIONALE: In heart failure (HF), CaMKII expression and reactive oxygen species (ROS) are increased. Both ROS and CaMKII can increase late I(Na) leading to intracellular Na accumulation and arrhythmias. It has been shown that ROS can activate CaMKII via oxidation. OBJECTIVE: We tested whether CaMKII...

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Main Authors: Wagner, Stefan, Ruff, Hanna M., Weber, Sarah L., Bellmann, Sarah, Sowa, Thomas, Schulte, Timo, Grandi, Eleonora, Bers, Donald M., Backs, Johannes, Belardinelli, Luiz, Maier, Lars S.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3065330/
https://ncbi.nlm.nih.gov/pubmed/21252154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.110.221911
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