Simulation of Ca-Calmodulin-Dependent Protein Kinase II on Rabbit Ventricular Myocyte Ion Currents and Action Potentials

Ca-calmodulin-dependent protein kinase II (CaMKII) was recently shown to alter Na(+) channel gating and recapitulate a human Na(+) channel genetic mutation that causes an unusual combined arrhythmogenic phenotype in patients: simultaneous long QT syndrome and Brugada syndrome. CaMKII is upregulated...

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Hlavní autoři: Grandi, Eleonora, Puglisi, Jose L., Wagner, Stefan, Maier, Lars S., Severi, Stefano, Bers, Donald M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2007
Témata:
Biophysical Theory and Modeling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084250/
https://ncbi.nlm.nih.gov/pubmed/17704163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.114868
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