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Calmodulin Mediates Differential Sensitivity of CaMKII and Calcineurin to Local Ca(2+) in Cardiac Myocytes

Calmodulin (CaM) mediates Ca-dependent regulation of numerous pathways in the heart, including CaM-dependent kinase (CaMKII) and calcineurin (CaN), yet the local Ca(2+) signals responsible for their selective activation are unclear. To assess when and where CaM, CaMKII, and CaN may be activated in t...

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Detalhes bibliográficos
Main Authors: Saucerman, Jeffrey J., Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2576378/
https://ncbi.nlm.nih.gov/pubmed/18689454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.108.128728
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