CaMKIIδ(C) Slows [Ca](i) Decline in Cardiac Myocytes by Promoting Ca Sparks

Acute activation of calcium/calmodulin-dependent protein kinase (CaMKII) in permeabilized phospholamban knockout (PLN-KO) mouse myocytes phosphorylates ryanodine receptors (RyRs) and activates spontaneous local sarcoplasmic reticulum (SR) Ca release events (Ca sparks) even at constant SR Ca load. To...

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Bibliographic Details
Main Authors: Guo, Tao, Zhang, Tong, Ginsburg, Kenneth S., Mishra, Shikha, Brown, Joan Heller, Bers, Donald M.
Format: Artigo
Language:Inglês
Published: The Biophysical Society 2012
Subjects:
Cellular Biophysics and Electrophysiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3368151/
https://ncbi.nlm.nih.gov/pubmed/22713561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.04.015
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