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Phospholamban ablation rescues SR Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIδ(C) transgenic mice
RATIONALE: We previously showed that transgenic mice expressing Ca(2+)/calmodulin-dependent protein kinase II δ(C) (CaMKII-TG) develop dilated cardiomyopathy associated with increased ryanodine receptors (RyR2) phosphorylation, enhanced sarcoplasmic reticulum (SR) Ca(2+) leak and lowering of SR Ca(2...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2818826/ https://ncbi.nlm.nih.gov/pubmed/19959778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.207423 |
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