Phospholamban ablation rescues SR Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIδ(C) transgenic mice

RATIONALE: We previously showed that transgenic mice expressing Ca(2+)/calmodulin-dependent protein kinase II δ(C) (CaMKII-TG) develop dilated cardiomyopathy associated with increased ryanodine receptors (RyR2) phosphorylation, enhanced sarcoplasmic reticulum (SR) Ca(2+) leak and lowering of SR Ca(2...

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Bibliografiske detaljer
Main Authors: Zhang, Tong, Guo, Tao, Mishra, Shikha, Dalton, Nancy D., Kranias, Evangelia G., Peterson, Kirk L., Bers, Donald M., Brown, Joan Heller
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2818826/
https://ncbi.nlm.nih.gov/pubmed/19959778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.207423
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