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The role of CaMKII regulation of phospholamban activity in heart disease
Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca(2)(+)-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser(16) by PKA or Thr(17) by Ca(2)(+)-calmodulin...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Frontiers Media S.A.
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3913884/ https://ncbi.nlm.nih.gov/pubmed/24550830 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00005 |
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