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CAMKII REGULATION OF PHOSPHOLAMBAN AND SR Ca(2+) LOAD
Phospholamban (PLN) is a small phosphoprotein in the cardiac sarcoplasmic reticulum (SR). Dephosphorylated PLN tonically inhibits the SR Ca(2+)-ATPase (SERCA2a) and phosphorylation of PLN, at either Ser(16) by PKA or Thr(17) by Ca(2+)-calmodulin-dependent protein kinase (CaMKII), reverses this inhib...
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3081991/ https://ncbi.nlm.nih.gov/pubmed/21111063 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2010.11.035 |
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