CaMKII Negatively Regulates Calcineurin-NFAT Signaling in Cardiac Myocytes

RATIONALE: Pathologic cardiac myocyte hypertrophy is thought to be induced by the persistent increases in intracellular Ca(2+) needed to maintain cardiac function when systolic wall stress is increased. Hypertrophic Ca(2+) binds to calmodulin (CaM) and activates the phosphatase calcineurin (Cn) and...

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Hlavní autoři: MacDonnell, Scott M., Weisser-Thomas, Jutta, Kubo, Hajime, Hanscome, Marie, Liu, Qinghang, Jaleel, Naser, Berretta, Remus, Chen, Xiongwen, Brown, Joan H., Sabri, Abdel-Karim, Molkentin, Jeffery D., Houser, Steven R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2765687/
https://ncbi.nlm.nih.gov/pubmed/19608982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.194035
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