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Does Contractile Ca(2+) Control Calcineurin-NFAT Signaling and Pathological Hypertrophy in Cardiac Myocytes?

In noncontractile cells, a sustained increase in total cytoplasmic Ca(2+) concentration is typically needed to activate the intracellular protein phosphatase calcineurin, leading to dephosphorylation of the transcription factor nuclear factor of activated T cells (NFAT), its nuclear translocation, a...

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Detalhes bibliográficos
Main Authors: Houser, Steven R., Molkentin, Jeffery D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2680250/
https://ncbi.nlm.nih.gov/pubmed/18577756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.125pe31
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