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β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model

A five-state model of myofilament contraction was integrated into a well-established rabbit ventricular myocyte model of ion channels, Ca(2+) transporters and kinase signaling to analyze the relative contribution of different phosphorylation targets to the overall mechanical response driven by β-adr...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Negroni, Jorge A., Morotti, Stefano, Lascano, Elena C., Gomes, Aldrin V., Grandi, Eleonora, Puglisi, José L, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380575/
https://ncbi.nlm.nih.gov/pubmed/25724724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.02.014
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