Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-dependent and β-Adrenergic Effects on Late Sodium, L-type Calcium and Sodium-Calcium Exchange Currents

BACKGROUND: Heart failure (HF) is characterized by electrophysiological remodeling resulting in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic currents in HF promote action potential (AP) prolongation, increased short-term variability of AP repolarization...

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Détails bibliographiques
Publié dans:Circ Arrhythm Electrophysiol
Auteurs principaux: Hegyi, Bence, Morotti, Stefano, Liu, Caroline, Ginsburg, Kenneth S., Bossuyt, Julie, Belardinelli, Luiz, Izu, Leighton T., Chen-Izu, Ye, Bányász, Tamás, Grandi, Eleonora, Bers, Donald M.
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720130/
https://ncbi.nlm.nih.gov/pubmed/30879336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.118.007061
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