Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-dependent and β-Adrenergic Effects on Late Sodium, L-type Calcium and Sodium-Calcium Exchange Currents

BACKGROUND: Heart failure (HF) is characterized by electrophysiological remodeling resulting in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic currents in HF promote action potential (AP) prolongation, increased short-term variability of AP repolarization...

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Vydáno v:Circ Arrhythm Electrophysiol
Hlavní autoři: Hegyi, Bence, Morotti, Stefano, Liu, Caroline, Ginsburg, Kenneth S., Bossuyt, Julie, Belardinelli, Luiz, Izu, Leighton T., Chen-Izu, Ye, Bányász, Tamás, Grandi, Eleonora, Bers, Donald M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720130/
https://ncbi.nlm.nih.gov/pubmed/30879336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.118.007061
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