β-adrenergic Regulation of Late Na(+) Current During Cardiac Action Potential Is Mediated by Both PKA and CaMKII

Late Na+ current (I(NaL)) significantly contributes to shaping cardiac action potentials (AP) and increased I(NaL) is associated with cardiac arrhythmias. β-adrenergic receptor (βAR) stimulation and its downstream signaling via protein kinase A (PKA) and Ca(2)+/calmodulin-dependent protein kinase II...

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Publicado en:J Mol Cell Cardiol
Main Authors: Bence, Hegyi, Bányász, Tamás, Izu, Leighton T., Belardinelli, Luiz, Bers, Donald M., Chen-Izu, Ye
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201263/
https://ncbi.nlm.nih.gov/pubmed/30240676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.09.006
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