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Balance Between Rapid Delayed Rectifier K(+) Current and Late Na(+) Current on Ventricular Repolarization: An Effective Antiarrhythmic Target?

BACKGROUND: Rapid delayed rectifier K(+) current (I(Kr)) and late Na(+) current (I(NaL)) significantly shape the cardiac action potential (AP). Changes in their magnitudes can cause either long or short QT syndromes (LQT, SQT) associated with malignant ventricular arrhythmias and sudden cardiac deat...

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Bibliografische gegevens
Gepubliceerd in:Circ Arrhythm Electrophysiol
Hoofdauteurs: Hegyi, Bence, Chen-Izu, Ye, Izu, Leighton T., Rajamani, Sridharan, Belardinelli, Luiz, Bers, Donald M., Bányász, Tamás
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331791/
https://ncbi.nlm.nih.gov/pubmed/32202931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.119.008130
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