Balance Between Rapid Delayed Rectifier K(+) Current and Late Na(+) Current on Ventricular Repolarization: An Effective Antiarrhythmic Target?

BACKGROUND: Rapid delayed rectifier K(+) current (I(Kr)) and late Na(+) current (I(NaL)) significantly shape the cardiac action potential (AP). Changes in their magnitudes can cause either long or short QT syndromes (LQT, SQT) associated with malignant ventricular arrhythmias and sudden cardiac deat...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Hegyi, Bence, Chen-Izu, Ye, Izu, Leighton T., Rajamani, Sridharan, Belardinelli, Luiz, Bers, Donald M., Bányász, Tamás
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7331791/
https://ncbi.nlm.nih.gov/pubmed/32202931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.119.008130
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