Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and Beta-adrenergic Effects on Delayed and Inward Rectifier Potassium Currents

BACKGROUND: Electrophysiological remodeling and increased susceptibility for cardiac arrhythmias are hallmarks of heart failure (HF). Ventricular action potential (AP) duration (APD) is typically prolonged in HF, with reduced repolarization reserve. However, underlying K(+) current changes are often...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Hegyi, Bence, Bossuyt, Julie, Ginsburg, Kenneth S., Mendoza, Lynette M., Talken, Linda, Ferrier, William T., Pogwizd, Steven M., Izu, Leighton T., Chen-Izu, Ye, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813707/
https://ncbi.nlm.nih.gov/pubmed/29437761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005852
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