Altered Repolarization Reserve in Failing Rabbit Ventricular Myocytes: Calcium and Beta-adrenergic Effects on Delayed and Inward Rectifier Potassium Currents

BACKGROUND: Electrophysiological remodeling and increased susceptibility for cardiac arrhythmias are hallmarks of heart failure (HF). Ventricular action potential (AP) duration (APD) is typically prolonged in HF, with reduced repolarization reserve. However, underlying K(+) current changes are often...

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Pubblicato in:Circ Arrhythm Electrophysiol
Autori principali: Hegyi, Bence, Bossuyt, Julie, Ginsburg, Kenneth S., Mendoza, Lynette M., Talken, Linda, Ferrier, William T., Pogwizd, Steven M., Izu, Leighton T., Chen-Izu, Ye, Bers, Donald M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5813707/
https://ncbi.nlm.nih.gov/pubmed/29437761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.117.005852
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