Enhanced Depolarization Drive in Failing Rabbit Ventricular Myocytes: Calcium-dependent and β-Adrenergic Effects on Late Sodium, L-type Calcium and Sodium-Calcium Exchange Currents

BACKGROUND: Heart failure (HF) is characterized by electrophysiological remodeling resulting in increased risk of cardiac arrhythmias. Previous reports suggest that elevated inward ionic currents in HF promote action potential (AP) prolongation, increased short-term variability of AP repolarization...

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Detalhes bibliográficos
Publicado no:Circ Arrhythm Electrophysiol
Main Authors: Hegyi, Bence, Morotti, Stefano, Liu, Caroline, Ginsburg, Kenneth S., Bossuyt, Julie, Belardinelli, Luiz, Izu, Leighton T., Chen-Izu, Ye, Bányász, Tamás, Grandi, Eleonora, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6720130/
https://ncbi.nlm.nih.gov/pubmed/30879336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCEP.118.007061
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