The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload

Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the transduction of calcium signals in the heart, but the...

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Bibliographic Details
Main Authors: Backs, Johannes, Backs, Thea, Neef, Stefan, Kreusser, Michael M., Lehmann, Lorenz H., Patrick, David M., Grueter, Chad E., Qi, Xiaoxia, Richardson, James A., Hill, Joseph A., Katus, Hugo A., Bassel-Duby, Rhonda, Maier, Lars S., Olson, Eric N.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650158/
https://ncbi.nlm.nih.gov/pubmed/19179290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813013106
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