Cardiac CaM Kinase II Genes δ and γ Contribute to Adverse Remodeling but Redundantly Inhibit Calcineurin-Induced Myocardial Hypertrophy

BACKGROUND: Ca(2+)-dependent signaling through CaM Kinase II (CaMKII) and calcineurin was suggested to contribute to adverse cardiac remodeling. However, the relative importance of CaMKII versus calcineurin for adverse cardiac remodeling remained unclear. METHODS AND RESULTS: We generated double-kno...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Circulation
Päätekijät: Kreusser, Michael M., Lehmann, Lorenz H., Keranov, Stanislav, Hoting, Marc-Oscar, Oehl, Ulrike, Kohlhaas, Michael, Reil, Jan-Christian, Neumann, Kay, Schneider, Michael D., Hill, Joseph A., Dobrev, Dobromir, Maack, Christoph, Maier, Lars S., Gröne, Hermann-Josef, Katus, Hugo A., Olson, Eric N., Backs, Johannes
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4316667/
https://ncbi.nlm.nih.gov/pubmed/25124496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.114.006185
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