Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels

In the preparation of synthetic conotoxins containing multiple disulfide bonds, oxidative folding can produce numerous permutations of disulfide bond connectivities. Establishing the native disulfide connectivities thus presents a significant challenge when the venom-derived peptide is not available...

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Main Authors: Khoo, Keith K., Gupta, Kallol, Green, Brad R., Zhang, Min-Min, Watkins, Maren, Olivera, Baldomero M., Balaram, Padmanabhan, Yoshikami, Doju, Bulaj, Grzegorz, Norton, Raymond S.
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131687/
https://ncbi.nlm.nih.gov/pubmed/23167564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301256s
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