Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels

In the preparation of synthetic conotoxins containing multiple disulfide bonds, oxidative folding can produce numerous permutations of disulfide bond connectivities. Establishing the native disulfide connectivities thus presents a significant challenge when the venom-derived peptide is not available...

Full description

Saved in:
Bibliographic Details
Main Authors: Khoo, Keith K., Gupta, Kallol, Green, Brad R., Zhang, Min-Min, Watkins, Maren, Olivera, Baldomero M., Balaram, Padmanabhan, Yoshikami, Doju, Bulaj, Grzegorz, Norton, Raymond S.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4131687/
https://ncbi.nlm.nih.gov/pubmed/23167564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi301256s
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items