2’f-OMe-phosphorodithioate modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity

Improving small interfering RNA (siRNA) efficacy in target cell populations remains a challenge to its clinical implementation. Here, we report a chemical modification, consisting of phosphorodithioate (PS2) and 2’-O-Methyl (2’-OMe) MePS2 on one nucleotide that significantly enhances potency and res...

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Autors principals: Wu, Sherry Y., Yang, Xianbin, Gharpure, Kshipra M., Hatakeyama, Hiroto, Egli, Martin, McGuire, Michael H., Nagaraja, Archana S., Miyake, Takahito M., Rupaimoole, Rajesha, Pecot, Chad V., Taylor, Morgan, Pradeep, Sunila, Sierant, Malgorzata, Rodriguez-Aguayo, Cristian, Choi, Hyun J., Previs, Rebecca A., Armaiz-Pena, Guillermo N., Huang, Li, Martinez, Carlos, Hassell, Tom, Ivan, Cristina, Sehgal, Vasudha, Singhania, Richa, Han, Hee-Dong, Su, Chang, Kim, Ji Hoon, Dalton, Heather J., Kowali, Chandra, Keyomarsi, Khandan, McMillan, Nigel A.J., Overwijk, Willem W., Liu, Jinsong, Lee, Ju-Seog, Baggerly, Keith A., Lopez-Berestein, Gabriel, Ram, Prahlad T., Nawrot, Barbara, Sood, Anil K.
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4112501/
https://ncbi.nlm.nih.gov/pubmed/24619206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4459
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