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Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate Substitutions
Chemically synthesized small interfering RNAs (siRNAs) have been widely used to identify gene function and hold great potential in providing a new class of therapeutics. Chemical modifications are desired for therapeutic applications to improve siRNA efficacy. Appropriately protected ribonucleoside-...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401229/ https://ncbi.nlm.nih.gov/pubmed/22512638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300078e |
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