Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate Substitutions

Chemically synthesized small interfering RNAs (siRNAs) have been widely used to identify gene function and hold great potential in providing a new class of therapeutics. Chemical modifications are desired for therapeutic applications to improve siRNA efficacy. Appropriately protected ribonucleoside-...

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Bibliografiske detaljer
Main Authors: Yang, Xianbin, Sierant, Malgorzata, Janicka, Magdalena, Peczek, Lukasz, Martinez, Carlos, Hassell, Tom, Li, Na, Li, Xin, Wang, Tianzhi, Nawrot, Barbara
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401229/
https://ncbi.nlm.nih.gov/pubmed/22512638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300078e
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