Evoking picomolar binding in RNA by a single phosphorodithioate linkage

RNA aptamers are synthetic oligonucleotide-based affinity molecules that utilize unique three-dimensional structures for their affinity and specificity to a target such as a protein. They hold the promise of numerous advantages over biologically produced antibodies; however, the binding affinity and...

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Publicat a:Nucleic Acids Res
Autors principals: Abeydeera, N. Dinuka, Egli, Martin, Cox, Nehemiah, Mercier, Karen, Conde, Jonas Nascimento, Pallan, Pradeep S., Mizurini, Daniella M., Sierant, Malgorzata, Hibti, Fatima-Ezzahra, Hassell, Tom, Wang, Tianzhi, Liu, Feng-Wu, Liu, Hong-Min, Martinez, Carlos, Sood, Anil K., Lybrand, Terry P., Frydman, Chiraz, Monteiro, Robson Q., Gomer, Richard H., Nawrot, Barbara, Yang, Xianbin
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2016
Matèries:
Chemical Biology and Nucleic Acid Chemistry
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041495/
https://ncbi.nlm.nih.gov/pubmed/27566147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw725
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